2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-113239S
    Hydroxycotinine-d3 1311275-10-1 98%
    Hydroxycotinine-d3 is deuterium labeled Hydroxycotinine. Hydroxycotinine is the main nicotine metabolite detected in smokers urine.
    Hydroxycotinine-d3
  • HY-113252R
    2-Methoxyestrone (Standard) 362-08-3
    Alitame (hydrate) (Standard) is the analytical standard of Alitame (hydrate). This product is intended for research and analytical applications. Alitame (hydrate) is a high-intensity sweetener formed from the amino acids L-aspartic acid and D-alanine, and an amine derived from thietane.
    2-Methoxyestrone (Standard)
  • HY-113252S
    2-Methoxyestrone-13C,d3 1217460-84-8 98%
    2-Methoxyestrone-13C,d3 is the 13C- and deuterium labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.
    2-Methoxyestrone-13C,d3
  • HY-113259R
    7α-Hydroxy-4-cholesten-3-one (Standard) 3862-25-7
    7α-Hydroxy-4-cholesten-3-one (Standard) is the analytical standard of 7α-Hydroxy-4-cholesten-3-one. This product is intended for research and analytical applications. 7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1.
    7α-Hydroxy-4-cholesten-3-one (Standard)
  • HY-113261R
    Oleoylcarnitine (Standard) 38677-66-6
    Oleoylcarnitine (Standard) is the analytical standard of Oleoylcarnitine. This product is intended for research and analytical applications. Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation.
    Oleoylcarnitine (Standard)
  • HY-113261S
    Oleoylcarnitine-d9 2847775-85-1 98%
    Oleoylcarnitine-d9 is deuterium labeled Oleoylcarnitine. Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation.
    Oleoylcarnitine-d9
  • HY-113266R
    Valerylcarnitine (Standard) 40225-14-7
    Valerylcarnitine (Standard) is the analytical standard of Valerylcarnitine. This product is intended for research and analytical applications. Valerylcarnitine is an endogenous metabolite, belonging to the short-chain acylcarnitines.
    Valerylcarnitine (Standard)
  • HY-113266S
    Valerylcarnitine-d9 2847775-89-5 98%
    Valerylcarnitine-d9 (C5:0 L-carnitine-d9) is the deuterium labeled Valerylcarnitine (HY-113266). Valerylcarnitine is an endogenous metabolite, belonging to the short-chain acylcarnitines.
    Valerylcarnitine-d9
  • HY-113268R
    Biotin sulfone (Standard) 40720-05-6
    Biotin sulfone (Standard) is the analytical standard of Biotin sulfone. This product is intended for research and analytical applications. Biotin sulfone is first isolated as a natural metabolite of biotin.
    Biotin sulfone (Standard)
  • HY-113273C
    Diadenosine pentaphosphate pentalithium 94108-02-8 98%
    Diadenosine pentaphosphate pentalithium is an endogenous vasoactive purine dinucleotide which has been isolated from thrombocytes. Diadenosine polyphosphates (ApnA, n=2–7) have been identified as constituents of secretory vesicles such as in platelets, chromaffin cells, Torpedo synaptic terminals and brain synaptosomes.
    Diadenosine pentaphosphate pentalithium
  • HY-113277R
    3-Methyladipic acid (Standard) 3058-01-3
    3-Methyladipic acid (Standard) is the analytical standard of 3-Methyladipic acid. This product is intended for research and analytical applications. 3-Methyladipic acid is the final metabolite in the ω-oxidation pathway.
    3-Methyladipic acid (Standard)
  • HY-113283S
    Homogentisic acid-13C6 1216468-48-2 98%
    Homogentisic acid-13C6 is the 13C-labeled Homogentisic acid (HY-113283). Homogentisic acid is a specific metabolite that accumulates in the urine and serum. Homogentisic acid can be used for diagnosis of alkaptonuria. Homogentisic acid is a phenolic acid.
    Homogentisic acid-13C6
  • HY-113315R
    3b-Hydroxy-5-cholenoic acid (Standard) 5255-17-4
    3b-Hydroxy-5-cholenoic acid (Standard) is an analytical standard for 3b-Hydroxy-5-cholenoic acid. This product is intended for research and analytical applications. 3b-Hydroxy-5-cholenoic acid is a monohydroxy bile acid of endogenous origin. 3b-Hydroxy-5-cholenoic acid can be used in the study of hepatic ductular hypoplasia syndrome.
    3b-Hydroxy-5-cholenoic acid (Standard)
  • HY-113315S
    3b-Hydroxy-5-cholenoic acid-d4 2770684-32-5 98%
    3b-Hydroxy-5-cholenoic acid-d4 is deuterium labeled 3b-Hydroxy-5-cholenoic acid (HY-113315). 3b-Hydroxy-5-cholenoic acid is a monohydroxy bile acid of endogenous origin.
    3b-Hydroxy-5-cholenoic acid-d4
  • HY-113334R
    Turanose (Standard) 547-25-1
    Turanose (Standard) is the analytical standard of Turanose. This product is intended for research and analytical applications. Turanose is an isomer of Sucrose that naturally exists in honey. Turanose has anti-inflammatory and regulates adipogenesis effect. Turanose has potential for obesity and related chronic diseases research[1][2].
    Turanose (Standard)
  • HY-113338A
    8-Hydroxyguanine hydrochloride 1246818-54-1 98%
    8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine hydrochloride induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine hydrochloride is a marker of DNA oxidative damage.
    8-Hydroxyguanine hydrochloride
  • HY-113365R
    Cholestenone (Standard) 601-57-0
    Clebopride (malate) (Standard) is the analytical standard of Clebopride (malate). This product is intended for research and analytical applications. Clebopride malate is a dopamine antagonist used in the study of functional gastrointestinal disorders.
    Cholestenone (Standard)
  • HY-113367S
    Suberylglycine-d4 2469259-73-0 ≥99.0%
    Suberylglycine-d4 is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid.
    Suberylglycine-d4
  • HY-113369S
    Cholesteryl arachidonate-d8 98%
    Cholesteryl arachidonate-d8 is deuterium labeled Cholesteryl arachidonate. Cholesteryl arachidonate is an endogenous metabolite.
    Cholesteryl arachidonate-d8
  • HY-113371R
    2-Methylcitric acid (Standard) 6061-96-7
    Omeprazole (sodium) (Standard) is the analytical standard of Omeprazole (sodium). This product is intended for research and analytical applications. Omeprazole sodium (H 16868 sodium), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole sodium shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM. Omeprazole sodium also inhibits growth of Gram-positive and Gram-negative bacteria. Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
    2-Methylcitric acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity